Abstract #0828

Intravoxel Incoherent Motion DWI and Aquaporins MR Imaging of Transplanted Kidneys at 3.0 T

Yanjun Li¹, Shumin Tao¹, Dandan Zheng², Yong Zhang², and Guangming Lu¹

¹Medical Imaging, Jingling Hospital, School of Medicine, Nanjing University, Nanjing, China, People's Republic of, ²GE Healthcare, MR Research China, Beijing, China, People's Republic of

Diffusion-weighted imaging (DWI) in human transplantation was regarded as a promising indicator for dectecting graft dysfunction.According to the IVIM theory, ADC integrates the effects of both diffusion of water molecules and microcirculation of blood in capillaries. By separating diffusion and perfusion, we could observe each component’s contribution to the changes of ADC values. Furthermore, the exchanges of intracellular water molecules with extracellular’s may have impact on ADC. Thus, AQP ADC might reflect quantitative water channel expression.

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