Diffusion Tensor Imaging and Histology of the Developing Myocardium
Osama M Abdullah1, MarJanna Dahl2, Gavin Yeip1, Julia Cortino1, Arnold David Gomez3, Thomas Seidel1, Frank Sachse1, Kurt Albertine2, and Edward W Hsu1
1Bioengineering, University of Utah, Salt Lake ity, UT, United States, 2Pediatric Neonatology, University of Utah, Salt Lake ity, UT, United States, 3Electrical and Computer Engineering, Johns Hopkins, Baltimore, MD, United States
Diffusion tensor imaging (DTI) has emerged as the method of
choice for noninvasive quantifications of myocardial microstructure. However,
the origins and behaviors of DTI measurements as functions of myocardial
remodeling during development remain poorly understood. In this work,
conventional and bi-compartmental DTI and histological correlation were
performed on an animal model of myocardial development to investigate the
effects of tissue remodeling. Results indicate that tissue remodeling during
development manifests in progressively increased DTI transverse diffusivities, decreased
fractional anisotropy, and unchanged fiber orientation. The findings show that
DTI can be used to noninvasively characterize microstructural remodeling of the
myocardium during development.
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