Abstract #0831

Diffusion Tensor Imaging and Histology of the Developing Myocardium

Osama M Abdullah¹, MarJanna Dahl², Gavin Yeip¹, Julia Cortino¹, Arnold David Gomez³, Thomas Seidel¹, Frank Sachse¹, Kurt Albertine², and Edward W Hsu¹

¹Bioengineering, University of Utah, Salt Lake ity, UT, United States, ²Pediatric Neonatology, University of Utah, Salt Lake ity, UT, United States, ³Electrical and Computer Engineering, Johns Hopkins, Baltimore, MD, United States

Diffusion tensor imaging (DTI) has emerged as the method of choice for noninvasive quantifications of myocardial microstructure. However, the origins and behaviors of DTI measurements as functions of myocardial remodeling during development remain poorly understood. In this work, conventional and bi-compartmental DTI and histological correlation were performed on an animal model of myocardial development to investigate the effects of tissue remodeling. Results indicate that tissue remodeling during development manifests in progressively increased DTI transverse diffusivities, decreased fractional anisotropy, and unchanged fiber orientation. The findings show that DTI can be used to noninvasively characterize microstructural remodeling of the myocardium during development.

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