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Abstract #0850

Atrophy computation in the spinal cord using the Boundary Shift Integral

Ferran Prados1,2, Marios C Yiannakas2, Manuel Jorge Cardoso1, Francesco Grussu2, Floriana De Angelis2, Domenico Plantone2, David H Miller2, Olga Ciccarelli2, Claudia Angela Michela Gandini Wheeler-Kingshott2,3, and Sebastien Ourselin1

1Translational Imaging Group, Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, University College London, London, United Kingdom, 3Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italy

In this work, we introduce a new pipeline based on the latest iteration of the BSI for computing atrophy in the SC and compare its results with the most popular atrophy measurements for this region, mean CSA. We demonstrated for the first time the use of BSI in the SC, as a sensitive, quantitative and objective measure of longitudinal tissue volume change. The BSI pipeline presented in this work is repeatable, reproducible and standardises a pipeline for computing SC atrophy.

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