Mohamed Tachrount1, Andrew Davies2, Roshni Desai2, Kenneth Smith2, David Thomas1, and Xavier Golay1
1Dept. of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, 2Dept. of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom
Perfusion-weighted imaging
studies have demonstrated that there is a widespread cerebral hypoperfusion in
patients with MS, regardless of the clinical subtype. The mechanism and the
role of hypoxia are still unclear. The purpose of this work was to
longitudinally investigate the SC blood flow (SCBF) during the different phases
of disease progression in EAE rats using an optimized ASL technique. These measurements
demonstrated for the first time on EAE animal model that the neurological
deficits are strongly correlated with impaired blood flow.
