Abstract #0899

3D Dynamic Hyperpolarized 13C-Pyruvate MR Metabolic Imaging of Human Prostate Cancer

Hsin-Yu Chen¹, Peder E.Z. Larson^1,2, Jeremy W. Gordon², Robert A. Bok², Marcus Ferrone³, Mark van Criekinge², Lucas Carvajal², Peng Cao², Ilwoo Park², Rahul Aggarwal⁴, Sarah J. Nelson^1,2, John Kurhanewicz^1,2, and Daniel B. Vigneron^1,2

¹Graduate Program in Bioengineering, UCSF and UC Berkeley, University of California, San Francisco, San Francisco, CA, United States, ²Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ³Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA, United States, ⁴Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA, United States

To measure the 3D spatial and temporal dynamics of hyperpolarized [1-¹³C]pyruvate for patient studies, a new compressed-sensing EPSI sequence was developed for prostate cancer clinical research. Utilizing multiband, variable flip angle RF excitation, this sequence provided high temporal (2s) and spatial (0.5cm³) resolution data detecting pyruvate uptake and its rate of conversion to lactate. This approach provided a significant advance over initial human HP-¹³C studies in which just 1D or 2D dynamics were measured and 15s single-timepoint 3D spectra were acquired. Following phantom tests, patient data demonstrated high pyruvate to lactate conversion in regions corresponding to biopsy-confirmed prostate cancer.

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