Abstract #0926

Post-mortem diffusion MRI of cervical spine and nerves roots

Wieke Haakma^1,2,3, Lidy Kuster², Martijn Froeling¹, Lars Uhrenholt², Michael Pedersen^3,4, Jeroen Hendrikse¹, Alexander Leemans⁵, and Lene Warner Thorup Boel²

¹Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ²Forensic Medicine, Aarhus University, Aarhus, Denmark, ³Comparative Medicine Lab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁴MR Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁵Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands

In this work we examined the architecture and diffusion measures of the cervical spine and nerves in non-fixated post-mortem subjects. We were able to display the architectural configuration of the cervical nerves at the level of C4-C8 and we computed reference values for the diffusion measures in these nerves. We showed with great detail the ventral and dorsal nerve roots with fiber tractography. Microscopic examination revealed normal anatomy. We expect that post-mortem diffusion MRI will be valuable for understanding of pathological mechanisms underlying degenerative neurological diseases, as it is possible to compare any findings directly to histological examinations.

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