Abstract #0928

Validation of quantitative MRI metrics using full slice histology with automatic axon segmentation

Tanguy Duval¹, Blanche Perraud¹, Manh-Tung Vuong¹, Nibardo Lopez Rios^1,2, Nikola Stikov^1,3, and Julien Cohen-Adad^1,4

¹Polytechnique Montréal, Montréal, QC, Canada, ²Medical Biophysics Center, Oriente University, Santiago de Cuba, Cuba, ³Montreal Heart Institute, Montréal, QC, Canada, ⁴Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montréal, QC, Canada

In this work we propose to validate and compare AxCaliber/ActiveAx/Noddi/MTV in the spinal cord using full slice histology with axon/myelin segmentation. High resolution data (150µm/px) were acquired on an ex vivo spinal cord and compared voxel by voxel with histology. We found that q-space metrics were precise enough to distinguish between various fiber distributions. A correlation coefficient of r=0.62 was found between AxCaliber and histology for axon diameter metric. Also, good agreement were found between the different q-space models and with MTV.

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