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Abstract #0928

Validation of quantitative MRI metrics using full slice histology with automatic axon segmentation

Tanguy Duval1, Blanche Perraud1, Manh-Tung Vuong1, Nibardo Lopez Rios1,2, Nikola Stikov1,3, and Julien Cohen-Adad1,4

1Polytechnique Montréal, Montréal, QC, Canada, 2Medical Biophysics Center, Oriente University, Santiago de Cuba, Cuba, 3Montreal Heart Institute, Montréal, QC, Canada, 4Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montréal, QC, Canada

In this work we propose to validate and compare AxCaliber/ActiveAx/Noddi/MTV in the spinal cord using full slice histology with axon/myelin segmentation. High resolution data (150µm/px) were acquired on an ex vivo spinal cord and compared voxel by voxel with histology. We found that q-space metrics were precise enough to distinguish between various fiber distributions. A correlation coefficient of r=0.62 was found between AxCaliber and histology for axon diameter metric. Also, good agreement were found between the different q-space models and with MTV.

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