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Abstract #0957

Thresholding to Improve the Specificity of High Spatial and Angular Resolution In Vivo Diffusion-Weighted Tractography to Estimate Brain Stem Connectivity.

Matthew Hey1, Luis Colon-Perez2, William Triplett3, David Fitzgerald4, and Thomas Mareci5

1University of Florida, Gainesville, FL, United States, 2Department of Psychiatry, University of Florida, Gainesville, FL, United States, 3Department of Physical Therapy, University of Florida, Gainesville, FL, United States, 4Department of Neurology, University of Florida College of Medicine, Gainesville, FL, United States, 5Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL, United States

The spatial resolution of diffusion-weighted (DWI) images limits the white matter streamline fiber tracks, which can be followed in the brain stem. To address this issue, we introduce a high spatial resolution protocol and the use of a threshold to limit the false positive in streamline track density maps by requiring that a minimum amount of fibers pass through a voxel. This provides increased accuracy in the visualization of streamlines connecting specific regions of the brain stem and may allow the recognition of structural abnormalities due to neurological diseases.

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