Abstract #0957

Thresholding to Improve the Specificity of High Spatial and Angular Resolution In Vivo Diffusion-Weighted Tractography to Estimate Brain Stem Connectivity.

Matthew Hey¹, Luis Colon-Perez², William Triplett³, David Fitzgerald⁴, and Thomas Mareci⁵

¹University of Florida, Gainesville, FL, United States, ²Department of Psychiatry, University of Florida, Gainesville, FL, United States, ³Department of Physical Therapy, University of Florida, Gainesville, FL, United States, ⁴Department of Neurology, University of Florida College of Medicine, Gainesville, FL, United States, ⁵Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL, United States

The spatial resolution of diffusion-weighted (DWI) images limits the white matter streamline fiber tracks, which can be followed in the brain stem. To address this issue, we introduce a high spatial resolution protocol and the use of a threshold to limit the false positive in streamline track density maps by requiring that a minimum amount of fibers pass through a voxel. This provides increased accuracy in the visualization of streamlines connecting specific regions of the brain stem and may allow the recognition of structural abnormalities due to neurological diseases.

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