Abstract #0963

Coronary Atherosclerosis T1-weighed Characterization with Integrated Anatomical Reference (CATCH): Comparison with High-risk Plaque Features on OCT

Yibin Xie¹, Young-Jin Kim², Jianing Pang¹, Qi Yang¹, Jung-Sun Kim³, Christopher T. Nguyen¹, Zixin Deng¹, Byoung Wook Choi², Zhaoyang Fan¹, Daniel S. Berman¹, Hyuk-Jae Chang³, and Debiao Li¹

¹Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, ³Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of

The aim of this work is to investigate the nature of pre-contrast and post-contrast T1w plaque hyper-intensity by comparing with coronary plaque morphology assessed by intracoronary optical coherence tomography (OCT). We scanned 13 healthy subjects and 30 stable angina patients using our recently developed whole-heart T1w coronary plaque characterization framework (CATCH). Compared with the classification based on OCT, we found that pre-contrast plaque to myocardial ratio (PMR) was significantly higher in the presence of large lipids, macrophages, and cholesterol crystals, whereas post-contrast PMR was significantly higher in the presence of macrophages and microvessels.

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