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Abstract #0973

Three-Dimensional Placental Perfusion Imaging Using Velocity-Selective Arterial Spin Labeling

Zungho Zun1, Ajit Shankaranarayanan2, Nickie Niforatos-Andescavage1, Samantha Bauer1, Diane Lanham1, Dorothy Bulas1, Adre J Du Plessis1, and Catherine Limperopoulos1

1Children’s National Medical Center, Washington, DC, United States, 2GE Healthcare, Menlo Park, CA, United States

Pregnancies complicated by placental insufficiency such as fetal growth restriction and preeclampsia are characterized by reduced placental perfusion. Conventional MR perfusion imaging involves the use of gadolinium-based contrast agents, which are contraindicated in pregnancy. In this study we demonstrate the utility of non-invasive placental perfusion imaging using velocity-selective arterial spin labeling and 3D image acquisition with whole placenta coverage, and present global and regional placental perfusion in high and low-risk pregnancies. Global placental perfusion matched ranges of previously reported values. However, perfusion was heterogeneous and regional placental perfusion measured within the placental lobules reached levels two-fold higher than the global placental perfusion measurement.

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