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Abstract #0985

Structural and hemodynamical contributions to brain T2* relaxation in schizophrenia, bipolar disorder and siblings

Jie Wen1, Daniel Mamah2, Jie Luo3, Xialing Ulrich1, Deanna Barch4, and Dmitriy Yablonskiy1

1Radiology, Washington University, Saint Louis, MO, United States, 2Psychiatry, Washington University, Saint Louis, MO, United States, 3Research Lab of Electronics, MIT, Cambridge, MA, United States, 4Psychology, Washington University, Saint Louis, MO, United States

Investigating brain structure and functioning by means of tissue-specific T2* relaxation properties in vivo can potentially guide the uncovering of neuropathology in psychiatric illness. In this abstract, R2* (=1/T2*) relaxation rate constant was separated into tissue-specific (R2*t) and hemodynamic BOLD contributions. 17 control, 17 bipolar disorder, 16 schizophrenia, and 12 unaffected schizophrenia sibling participants were scanned. A MANOVA of 38 gray matter regions showed significant group effects for BOLD but not for R2*t. Our results suggest that increased baseline activity in certain brain regions is part of the underlying pathophysiology of specific psychiatric disorders.

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