Abstract #1012

Tailored Spiral In-Out Spectral-Spatial Saturation Pulses for Short and Effective Water Suppression in High Resolution MRSI

Jun Ma¹, Carrie Wismans², Zhipeng Cao¹, Dennis W. J. Klomp², Jannie P. Wijnen², and William A. Grissom^1,3

¹Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, ²Department of Radiology, University Medical Centre Utrecht, Utrecht, Netherlands, ³Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

At ultra-high field (7T and above), the increased SNR can be used to significantly improve MRSI spatial resolution, but scan time is a challenge with large acquisition matrixes, so time-efficient water signal suppression is critical. However, at ultra-high field, B1⁺ and B0 inhomogeneities degrade the performance of time-efficient CHESS water suppression strategies. To address this, we propose to replace conventional spectrally-selective pulses with subject-tailored spiral in-out spectral-spatial (SPSP) saturation pulses that are designed using subject-specific B1⁺ and B0 maps. The pulses were validated in in vivo experiments.

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