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Abstract #1012

Tailored Spiral In-Out Spectral-Spatial Saturation Pulses for Short and Effective Water Suppression in High Resolution MRSI

Jun Ma1, Carrie Wismans2, Zhipeng Cao1, Dennis W. J. Klomp2, Jannie P. Wijnen2, and William A. Grissom1,3

1Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2Department of Radiology, University Medical Centre Utrecht, Utrecht, Netherlands, 3Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

At ultra-high field (7T and above), the increased SNR can be used to significantly improve MRSI spatial resolution, but scan time is a challenge with large acquisition matrixes, so time-efficient water signal suppression is critical. However, at ultra-high field, B1+ and B0 inhomogeneities degrade the performance of time-efficient CHESS water suppression strategies. To address this, we propose to replace conventional spectrally-selective pulses with subject-tailored spiral in-out spectral-spatial (SPSP) saturation pulses that are designed using subject-specific B1+ and B0 maps. The pulses were validated in in vivo experiments.

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