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Abstract #1030

The impact of ebselen administration on neurochemical profiles: A magnetic resonance spectroscopy study at 7 Tesla

Uzay E Emir1, Charles Masaki2, Ann L Sharpley2, Beata R Godlewska2, Adam Berrington1, Tasuku Hashimoto2, Nisha Singh3, Sridhar R Vasudevan3, Grant C Churchill3, and Philip J Cowen2

1FMRIB Centre, University of Oxford, Oxford, United Kingdom, 2Department of Psychiatry, University of Oxford, Oxford, United Kingdom, 3Department of Pharmacology, University of Oxford, Oxford, United Kingdom

Bipolar disorder (BPD) is a relatively common psychiatric disorder for which lithium is the gold standard of treatment. Lithium is an inhibitor of the enzyme inositol monophosphatase (IMPase) , leading to marked decreases in brain myo -inositol (myo -Ins) levels Recently, it has been reported that ebselen, a drug developed for its antioxidant and inflammatory properties, inhibits IMPase and lowers myo -Ins levels in the human brain. In this study, it was aimed to replicate this finding using a higher dose of ebselen and at ultra high field strength (7T).

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