Uzay E Emir1, Charles Masaki2, Ann L Sharpley2, Beata R Godlewska2, Adam Berrington1, Tasuku Hashimoto2, Nisha Singh3, Sridhar R Vasudevan3, Grant C Churchill3, and Philip J Cowen2
1FMRIB Centre, University of Oxford, Oxford, United Kingdom, 2Department of Psychiatry, University of Oxford, Oxford, United Kingdom, 3Department of Pharmacology, University of Oxford, Oxford, United Kingdom
Bipolar disorder (BPD) is a relatively common psychiatric
disorder for which lithium is the gold standard of treatment. Lithium is an inhibitor of the enzyme inositol monophosphatase
(IMPase) , leading to marked decreases in
brain myo -inositol (myo -Ins) levels
Recently, it has been reported that
ebselen, a drug developed for its
antioxidant and inflammatory properties,
inhibits IMPase and lowers myo -Ins
levels
in
the human brain. In this study, it was aimed to replicate this finding using a higher dose of
ebselen and at ultra high field strength (7T).
