Abstract #1030

The impact of ebselen administration on neurochemical profiles: A magnetic resonance spectroscopy study at 7 Tesla

Uzay E Emir¹, Charles Masaki², Ann L Sharpley², Beata R Godlewska², Adam Berrington¹, Tasuku Hashimoto², Nisha Singh³, Sridhar R Vasudevan³, Grant C Churchill³, and Philip J Cowen²

¹FMRIB Centre, University of Oxford, Oxford, United Kingdom, ²Department of Psychiatry, University of Oxford, Oxford, United Kingdom, ³Department of Pharmacology, University of Oxford, Oxford, United Kingdom

Bipolar disorder (BPD) is a relatively common psychiatric disorder for which lithium is the gold standard of treatment. Lithium is an inhibitor of the enzyme inositol monophosphatase (IMPase) , leading to marked decreases in brain myo -inositol (myo -Ins) levels Recently, it has been reported that ebselen, a drug developed for its antioxidant and inflammatory properties, inhibits IMPase and lowers myo -Ins levels in the human brain. In this study, it was aimed to replicate this finding using a higher dose of ebselen and at ultra high field strength (7T).

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