Abstract #1032

Assessing the effects of methylphenidate on human brain development using pharmacological magnetic resonance imaging: a randomized controlled trial

Anouk Schrantee¹, Esther E Bron², Henk-Jan MM Mutsaerts^1,3, Stefan Klein², Wiro Niessen^2,4, Serge ARB Rombouts^5,6, and Liesbeth Reneman¹

¹Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus MC, Rotterdam, Netherlands, ³Sunnybrook Research Institute, Toronto, ON, Canada, ⁴Imaging Physics, Applied Sciences, Delft University of Technology, Delft, Netherlands, ⁵Institute of Psychology, Leiden University, Leiden, Netherlands, ⁶Department of Radiology, LUMC, Leiden, Netherlands

In this randomized clinical trial we studied the effect of methylphenidate exposure on the development of the dopamine system in children and adults with ADHD. Concurrent with preclinical literature, we found an increased DA reactivity using arterial spin labeling pharmacological MRI following four months of treatment with methylphenidate in children with ADHD, but not in adult patients.

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