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Abstract #1032

Assessing the effects of methylphenidate on human brain development using pharmacological magnetic resonance imaging: a randomized controlled trial

Anouk Schrantee1, Esther E Bron2, Henk-Jan MM Mutsaerts1,3, Stefan Klein2, Wiro Niessen2,4, Serge ARB Rombouts5,6, and Liesbeth Reneman1

1Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus MC, Rotterdam, Netherlands, 3Sunnybrook Research Institute, Toronto, ON, Canada, 4Imaging Physics, Applied Sciences, Delft University of Technology, Delft, Netherlands, 5Institute of Psychology, Leiden University, Leiden, Netherlands, 6Department of Radiology, LUMC, Leiden, Netherlands

In this randomized clinical trial we studied the effect of methylphenidate exposure on the development of the dopamine system in children and adults with ADHD. Concurrent with preclinical literature, we found an increased DA reactivity using arterial spin labeling pharmacological MRI following four months of treatment with methylphenidate in children with ADHD, but not in adult patients.

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