Abstract #1035

MEGAPRESS reveals lower γ-aminobutyric acid ratios in the striatum of highly-impulsive rats

Stephen J Sawiak¹, Bianca Jupp¹, Tom Taylor¹, Daniele Caprioli¹, T Adrian Carpenter¹, and Jeffrey Dalley¹

¹University of Cambridge, Cambridge, United Kingdom

Disorders of impulse control are a rising issue in society as diagnosis rates of conditions such as attention deficit and hyperactivity disorder are increasing. In humans, the MEGAPRESS approach to measuring GABA is becoming a standard technique but it has not yet been used much in translational studies. Here, we used it to measure GABA in the striatum of highly-impulsive rats compared to rats with low impulsivity and found significantly reduced levels of this inhibitory neurotransmitter in the impulsive animals.

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