Abstract #1041

HIgh B-value and high Resolution Integrated Diffusion (HIBRID) Imaging

Qiuyun Fan¹, Aapo Nummenmaa¹, Jonathan R. Polimeni¹, Thomas Witzel¹, Susie Y. Huang¹, Van J. Wedeen¹, Bruce R. Rosen^1,2, and Lawrence L. Wald^1,2

¹Massachusetts General Hospital, Boston, MA, United States, ²Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, MA, United States

The cerebral cortex is rich in gyral folding. Axonal fibers take sharp turns when bending into the cortex. High resolution diffusion MRI is needed to characterize cortical structures in finer scale, while high b-value is desired to resolve complex white matter structures. We examined the impact of imaging resolution on characterizing the radial diffusion pattern in cortex, and proposed to improve the HIgh B-value and high Resolution Integrated Diffusion (HIBRID) imaging by incorporating information about each voxel’s proximity to the cortex. The combined data demonstrated the desired features from both high resolution and high b-value diffusion imaging.

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