Abstract #1046

Investigating the effects of intrinsic diffusivity on neurite orientation dispersion and density imaging (NODDI)

Jose M Guerrero¹, Nagesh Adluru², Steven R Kecskemeti², Richard J Davidson³, and Andrew L Alexander¹

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Waisman Center, University of Wisconsin - Madison, Madison, WI, United States, ³Psychology and Psychiatry, University of Wisconsin - Madison, Madison, WI, United States

NODDI model and its widely used estimation toolbox assume the intracellular (or intrinsic) diffusivity (ID) to a fixed value suitable for healthy adult brains. For broader applicability of the model in neurological diseases it is important to understand the effects of ID. Using multi-shell diffusion data we investigated the variability of estimated NODDI indices as well as the model residuals with respect to variations in ID. Our results suggest that the value for ID cannot simply be set to that offering the least residual since there are appreciable effects on the indices even in a small range of ID values.

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