Abstract #1067

Vessel wall thickness measurements of the circle of Willis using 7.0T MRI

Anita A. Harteveld¹, Anja G. van der Kolk¹, Nerissa P. Denswil², Jeroen C.W. Siero¹, Hugo J. Kuijf³, Aryan Vink⁴, Wim G.M. Spliet⁴, Peter R. Luijten¹, Mat J. Daemen², Jaco J.M. Zwanenburg^1,3, and Jeroen Hendrikse¹

¹Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ²Pathology, Academic Medical Center, Amsterdam, Netherlands, ³Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Pathology, University Medical Center Utrecht, Utrecht, Netherlands

In the last decade, several MRI sequences have been developed for direct visualization of the intracranial vessel wall. Although much is known about vessel wall (intima-media) thickness of extracranial arteries, less is known about the intracranial arterial vessel wall. In the current study, vessel wall thickness of major intracranial arteries was measured in ex vivo samples of the circle of Willis, using 7T MRI and histological validation, to ultimately provide a reference guide for normal intracranial vessel wall thickness. The results show that ultrahigh-resolution MRI at 7T enables accurate measurement of vessel wall thickness in ex vivo CoW specimens.

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