Jiaying Zhang1, Aurobrata Ghosh1, Daniel C Alexander1, and Gary Hui Zhang1
and function of human brain evolve across the lifespan. The microstructural white matter changes across
lifespan have been studied using Diffusion tensor imaging. Whilst sensitive, DTI
parameters have no direct tissue specificity. Here, given the availability of high-quality
HCP lifespan dataset, we aim to study the lifespan trajectory of
microstructural WM changes using NODDI and evaluate another NODDI fitting
framework - Accelerated microstructure imaging via convex optimization (AMICO).
We found U-shaped neurite density changes across lifespan and feasibility of AMICO
NODDI parameters in capturing the similar lifespan trajectory as the standard fitting.