Abstract #1079

The lifespan trajectory of white matter microstructure detected by NODDI

Jiaying Zhang¹, Aurobrata Ghosh¹, Daniel C Alexander¹, and Gary Hui Zhang¹

¹Computer Science and Centre for medical image computing, University College London, London, United Kingdom

The structure and function of human brain evolve across the lifespan. The microstructural white matter changes across lifespan have been studied using Diffusion tensor imaging. Whilst sensitive, DTI parameters have no direct tissue specificity. Here, given the availability of high-quality HCP lifespan dataset, we aim to study the lifespan trajectory of microstructural WM changes using NODDI and evaluate another NODDI fitting framework - Accelerated microstructure imaging via convex optimization (AMICO). We found U-shaped neurite density changes across lifespan and feasibility of AMICO NODDI parameters in capturing the similar lifespan trajectory as the standard fitting.

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