Measurement of restricted and hindered anisotropic diffusion tissue compartments in a rat model of Wallerian degeneration
Benoit Scherrer1, Damien Jacobs2, Maxime Taquet1,2, Anne des Rieux3, Benoit Macq2, Sanjay P Prabhu1, and Simon K Warfield1
1Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, 2ICTEAM, Universite catholique de Louvain, Louvain-La-Neuve, Belgium, 3LDRI, Université catholique de Louvain, Brussels, Belgium
The DIAMOND model has been recently proposed to model the
heterogeneity of tissue compartments in diffusion compartment imaging. However,
it did not enable the characterization of the intra-axonal volume fraction
(IAVF), a critical measure to more accurately characterizing axonal loss in abnormal
tissues. In this work we investigated mathematical extensions to DIAMOND that model
both the IAVF and the heterogeneous nature of in-vivo tissue. We validated our
approach using both Monte-Carlo simulations and histological microscopy with an animal model of Wallerian degeneration. We
show that our novel model better predicts the signal and provides additional
parameters to further describe tissues.
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