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Abstract #1087

Measurement of restricted and hindered anisotropic diffusion tissue compartments in a rat model of Wallerian degeneration

Benoit Scherrer1, Damien Jacobs2, Maxime Taquet1,2, Anne des Rieux3, Benoit Macq2, Sanjay P Prabhu1, and Simon K Warfield1

1Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, 2ICTEAM, Universite catholique de Louvain, Louvain-La-Neuve, Belgium, 3LDRI, Université catholique de Louvain, Brussels, Belgium

The DIAMOND model has been recently proposed to model the heterogeneity of tissue compartments in diffusion compartment imaging. However, it did not enable the characterization of the intra-axonal volume fraction (IAVF), a critical measure to more accurately characterizing axonal loss in abnormal tissues. In this work we investigated mathematical extensions to DIAMOND that model both the IAVF and the heterogeneous nature of in-vivo tissue. We validated our approach using both Monte-Carlo simulations and histological microscopy with an animal model of Wallerian degeneration. We show that our novel model better predicts the signal and provides additional parameters to further describe tissues.

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