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Abstract #1158

Impact of acquisition parameters on cortical thickness and volume derived from Multi-Echo MPRAGE scans

Ross W. Mair1,2, Martin Reuter2,3, and Andre J. van der Kouwe2

1Center for Brain Science, Harvard University, Cambridge, MA, United States, 2A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 3Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States

The multi-echo MPRAGE (MEMPRAGE) sequence was implemented to reduce signal distortion by acquiring at a higher bandwidth and averaging multiple echoes to recover SNR while providing additional T2* information that can enhance cortical segmentation. A rapid 2-minute MEMPRAGE protocol has been implemented for large multi-center studies. Here, we investigate the impact on morphometric results for the cortex by systematically varying all the parameters modified between the rapid 2-minute scan and a conventional 6-minute structural scan. Small but significant differences in cortical thickness and gray matter volume result from a combination of the use of partial fourier acquisition and lowering the spatial resolution to 1.2mm.

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