Cross-validation of a CSF MRI sequence for calculating brain volume by comparison with brain segmentation methods
Lisa A. van der Kleij1, Jeroen de Bresser1, Esben T. Petersen2, Jeroen Hendrikse1, and Jill B. De Vis1
1Department of Radiology, UMC Utrecht, Utrecht, Netherlands, 2Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
We
recently introduced a CSF MRI sequence to automatically
measure intracranial volume (ICV) and brain parenchymal volume (BPV). This
sequence with short imaging time (0:57 min) and fast post processing correlates well with qualitative brain atrophy scores. This
study demonstrates that the low resolution and high resolution CSF MRI sequences perform well in the
assessment of BPV and ICV, with a precision similar to the conventional brain
segmentation methods FSL, Freesurfer and SPM. The CSF MRI sequence showed a good to very good correlation with the conventional segmentation methods for ICV and BPV.
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