Abstract #1164

Cross-validation of a CSF MRI sequence for calculating brain volume by comparison with brain segmentation methods

Lisa A. van der Kleij¹, Jeroen de Bresser¹, Esben T. Petersen², Jeroen Hendrikse¹, and Jill B. De Vis¹

¹Department of Radiology, UMC Utrecht, Utrecht, Netherlands, ²Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark

We recently introduced a CSF MRI sequence to automatically measure intracranial volume (ICV) and brain parenchymal volume (BPV). This sequence with short imaging time (0:57 min) and fast post processing correlates well with qualitative brain atrophy scores. This study demonstrates that the low resolution and high resolution CSF MRI sequences perform well in the assessment of BPV and ICV, with a precision similar to the conventional brain segmentation methods FSL, Freesurfer and SPM. The CSF MRI sequence showed a good to very good correlation with the conventional segmentation methods for ICV and BPV.

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