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Abstract #1166

Evaluating the variability of multicenter and longitudinal hippocampal volume measurements.

Stephanie Bogaert1, Michiel de Ruiter2, Sabine Deprez3,4, Ronald Peeters3, Pim Pullens5,6, Frank De Belder6, José Belderbos7, Sanne Schagen2, Dirk De Ruysscher8,9, Stefan Sunaert3,4, and Eric Achten1

1Radiology, Ghent University Hospital, Ghent, Belgium, 2Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, Netherlands, 3Radiology, Leuven University Hospital, Belgium, 4Imaging and Pathology, KU Leuven, Belgium, 5Radiology, University of Antwerp, Belgium, 6Radiology, Antwerp University Hospital, Belgium, 7Radiation Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands, 8Radiation Oncology, MAASTRO clinic Maastricht, Netherlands, 9Respiratory Oncology, Maastricht University Medical Center, Netherlands

Longitudinal multicenter MRI studies require stable and comparable measurements. We scanned two subjects in six different scanners (two vendors) at different time points and assessed hippocampal volumes manually and automatically.

Intrascanner CV was <2.62% for both techniques; Freesurfer is a good alternative for manual delineation for longitudinal studies.

Intervendor variability was sometimes lower than intrascanner variability for the manual technique, which suggests only a modest effect of hardware differences across vendors. Freesurfer results were systematically higher for vendor B compared to A; it is not recommended to compare cross-sectional Freesurfer results between vendors in this multicenter study.

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