Meeting Banner
Abstract #1183

Are Negative BOLD Responses Induced by Acupuncture Associated with Neural Inhibitive Effects? : an MRS & BOLD Functional MRI Study

Jiliang Fang1, Yanping Zhao1, Sinyeob Ahn2, Guiyong Liu1, Caixia Fu3, Jin Yang1, Xiaoling Wang1, Bo Hou4, Feng Feng4, and Tianyi Qian5

1Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China, People's Republic of, 2MR Collaboration, Siemens Healthcare, San Francisco, CA, United States, 3APPL, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, People's Republic of, 4Radiology, Peking Union Medical College Hospital, Beijing, China, People's Republic of, 5MR Collaborations NE Asia, Siemens Healthcare, Beijing, China, People's Republic of

This study investigates the neurotransmitter basis of the negative response in the medial prefrontal cortex induced by acupuncture stimulus. The MEGA-PRESS 1H-MRS sequence was used to detect the gamma-aminobutyric acid (GABA) and Glutamine (Glu) concentration before and after acupuncture stimulation in normal subjects. The result showed that the GABA concentrations were decreased, while the Glu/Gln concentrations were increased. The task-fMRI data acquired during acupuncture stimulation showed deactivation in the same area. These results suggest that the deactivated BOLD response induced by acupuncture might be associated with the neural inhibition effects.

This abstract and the presentation materials are available to members only; a login is required.

Join Here