Abstract #1183

Are Negative BOLD Responses Induced by Acupuncture Associated with Neural Inhibitive Effects? : an MRS & BOLD Functional MRI Study

Jiliang Fang¹, Yanping Zhao¹, Sinyeob Ahn², Guiyong Liu¹, Caixia Fu³, Jin Yang¹, Xiaoling Wang¹, Bo Hou⁴, Feng Feng⁴, and Tianyi Qian⁵

¹Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China, People's Republic of, ²MR Collaboration, Siemens Healthcare, San Francisco, CA, United States, ³APPL, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, People's Republic of, ⁴Radiology, Peking Union Medical College Hospital, Beijing, China, People's Republic of, ⁵MR Collaborations NE Asia, Siemens Healthcare, Beijing, China, People's Republic of

This study investigates the neurotransmitter basis of the negative response in the medial prefrontal cortex induced by acupuncture stimulus. The MEGA-PRESS 1H-MRS sequence was used to detect the gamma-aminobutyric acid (GABA) and Glutamine (Glu) concentration before and after acupuncture stimulation in normal subjects. The result showed that the GABA concentrations were decreased, while the Glu/Gln concentrations were increased. The task-fMRI data acquired during acupuncture stimulation showed deactivation in the same area. These results suggest that the deactivated BOLD response induced by acupuncture might be associated with the neural inhibition effects.

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