Abstract #1188

Investigation of 1H MRS changes in the brain of osteoarthritis patients in relation to perceived pain

Franklyn Arron Howe¹, Olakunbi Harrison², Thomas Richard Barrick¹, and Nidhi Sofat²

¹Neuroscience Research Centre, St George's, University of London, London, United Kingdom, ²Institute for Infection and Immunity, St George's, University of London, London, United Kingdom

Chronic pain from osteoarthritis (OA) may be aggravated by “central sensitisation”, whereby pain-processing pathways become sensitised by inflammatory and degenerative disease processes. 1H MRS was used to investigate biochemical changes in pain processing brain areas of hand OA patients (n=32) compared to controls (n=14). There were no differences between controls and patients in the anterior cingulate gyrus, nor age related changes. In the insula cortex mI/Glx correlated with the pain score (R2 = 0.52, p = 0.018) after co-varying for age. High mI/Glx in the insula cortex was associated with high pain and may reflect inflammatory effects or neurological changes.

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