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Abstract #1188

Investigation of 1H MRS changes in the brain of osteoarthritis patients in relation to perceived pain

Franklyn Arron Howe1, Olakunbi Harrison2, Thomas Richard Barrick1, and Nidhi Sofat2

1Neuroscience Research Centre, St George's, University of London, London, United Kingdom, 2Institute for Infection and Immunity, St George's, University of London, London, United Kingdom

Chronic pain from osteoarthritis (OA) may be aggravated by “central sensitisation”, whereby pain-processing pathways become sensitised by inflammatory and degenerative disease processes. 1H MRS was used to investigate biochemical changes in pain processing brain areas of hand OA patients (n=32) compared to controls (n=14). There were no differences between controls and patients in the anterior cingulate gyrus, nor age related changes. In the insula cortex mI/Glx correlated with the pain score (R2 = 0.52, p = 0.018) after co-varying for age. High mI/Glx in the insula cortex was associated with high pain and may reflect inflammatory effects or neurological changes.

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