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Abstract #1193

Reduced low frequency band power in resting state activity predicts symptom severity in mild traumatic brain injury (mTBI)

Radhika Madhavan1, Suresh E Joel1, Sumit Niogi2, John A Tsiouris2, Luca Marinelli3, and Teena Shetty2

1GE Global Research, Bangalore, India, 2Hospital for special surgery, New York, NY, United States, 3GE Global Research, Niskayuna, NY, United States

mTBI diagnosis is controversial since although the brain appears normal on CT/MRI scans, a significant proportion of patients display persistent cognitive impairments up to 6 months post-injury. We recorded rs-fMRI in mTBI patients longitudinally over 3 months, to track functional changes in the brain as patients recovered. Symptom scores were negatively correlated with fractional power in the low-frequency band (0.01-0.1 Hz) of rs-fMRI, and this correlation was most significant in the higher visual, salience and sensorimotor networks. We suggest that low frequency power of rs-fMRI can be used as a biomarker for predicting severity of cognitive impairment in brain injury.

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