Abstract #1193

Reduced low frequency band power in resting state activity predicts symptom severity in mild traumatic brain injury (mTBI)

Radhika Madhavan¹, Suresh E Joel¹, Sumit Niogi², John A Tsiouris², Luca Marinelli³, and Teena Shetty²

¹GE Global Research, Bangalore, India, ²Hospital for special surgery, New York, NY, United States, ³GE Global Research, Niskayuna, NY, United States

mTBI diagnosis is controversial since although the brain appears normal on CT/MRI scans, a significant proportion of patients display persistent cognitive impairments up to 6 months post-injury. We recorded rs-fMRI in mTBI patients longitudinally over 3 months, to track functional changes in the brain as patients recovered. Symptom scores were negatively correlated with fractional power in the low-frequency band (0.01-0.1 Hz) of rs-fMRI, and this correlation was most significant in the higher visual, salience and sensorimotor networks. We suggest that low frequency power of rs-fMRI can be used as a biomarker for predicting severity of cognitive impairment in brain injury.

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