Abstract #1226

Distinct atrophy of subcortical structures demonstrates gender-specific changes in ALS

Qiuli Zhang¹, Ming Zhang¹, Jingxia Dang², Jiaoting Jin², Fang Hu², Haining Li¹, Dandan Zheng³, and Yuchen Zhang⁴

¹Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, People's Republic of, ²Department of Neurology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, People's Republic of, ³GE Healthcare, MR Research China, Beijing, China, People's Republic of, ⁴Zonglian College, Xi'an Jiaotong University, Xi'an, China, People's Republic of

Clinical heterogeneity is a feature in ALS. Here we analyzed subcortical structure volume and executive function between male and female ALS patients, compared with corresponding normal controls. Our results showed that male and female patients exhibited distinct subcortical structure atrophy. The linear regression results also indicated that compared with male patients, whose cognitive status was mostly related with age and education level, the executive dusfunction in female patients may be deteriorated by emotional disorder.

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