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Abstract #1226

Distinct atrophy of subcortical structures demonstrates gender-specific changes in ALS

Qiuli Zhang1, Ming Zhang1, Jingxia Dang2, Jiaoting Jin2, Fang Hu2, Haining Li1, Dandan Zheng3, and Yuchen Zhang4

1Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, People's Republic of, 2Department of Neurology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, People's Republic of, 3GE Healthcare, MR Research China, Beijing, China, People's Republic of, 4Zonglian College, Xi'an Jiaotong University, Xi'an, China, People's Republic of

Clinical heterogeneity is a feature in ALS. Here we analyzed subcortical structure volume and executive function between male and female ALS patients, compared with corresponding normal controls. Our results showed that male and female patients exhibited distinct subcortical structure atrophy. The linear regression results also indicated that compared with male patients, whose cognitive status was mostly related with age and education level, the executive dusfunction in female patients may be deteriorated by emotional disorder.

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