Abstract #1259

Cerebral Blood Flow Measured by Arterial Spin Labeled MRI Predicts Longitudinal Hippocampal Atrophy in Mild Cognitive Impairment

Long Xie^1,2, Sandhitsu R. Das^1,3, Arun Pilania^3,4, Molly Daffner^3,4, Grace E. Stockbower^3,4, Sudipto Dolui^3,5,6, John A. Detre^3,5,6, and David A. Wolk^3,4

¹Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States, ⁴Penn Memory Center, University of Pennsylvania, Philadelphia, PA, United States, ⁵Center for Functional Neuroimaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁶Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

In this study, we compared regional cerebral blood flow (CBF) measured by arterial spin labeled perfusion MRI (ASL-MRI) with baseline hippocampal volume from structural MRI in predicting likely Alzheimer’s disease (AD) progression measured by longitudinal hippocampal atrophy. Stepwise linear regression analyses demonstrated that CBF measurements were significantly associated with longitudinal hippocampal atrophy in entire cohort, as well as just within the MCI patients, while baseline hippocampal volume does not provide complementary information. Our results indicate ASL-MRI could potentially have important utility in identifying candidates for AD related therapeutic intervention studies and clinical trials.

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