Abstract #1261

Quantitative Susceptibility Mapping in Patients with Alzheimer's Disease and Mild Cognitive Impairment

Hyug-Gi Kim¹, Chan-Hee Lee¹, Chang-Woo Ryu², Soonchan Park², Hak Young Rhee³, Kyung Mi Lee⁴, Wook Jin², Dal-Mo Yang², Soo Yeol Lee¹, Tian Liu⁵, Yi Wang⁵, and Geon-Ho Jahng²

¹Biomedical Engineering, Kyung Hee University, Gyeonggi-do, Korea, Republic of, ²Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ³Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ⁴Radiology, Kyung Hee University Hospital, Seoul, Korea, Republic of, ⁵Biomedical Engineering and Radiology, Cornell University, New York, NY, United States

One of the important characteristics of Alzheimer’s disease (AD) is the iron accumulations in the brain. To estimate the quantitative susceptibility effects in AD brain, the susceptibility changes were investigated in subjects with 19 cognitive normal (CN), 19 mild cognitive impairment (MCI) and 19 AD. Seven-echo 3D gradient-echo images were obtained to map quantitative susceptibility mapping (QSM) and 3D T1-weighted images using the MPRAGE sequence were also obtained to map gray matter volume (GMV). Both voxel-based and ROI-based analyses were performed to evaluate the group differences. The result showed that QSM can be useful to evaluate the AD brain.

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