Abstract #1263

Correlation of 2-year longitudinal structural changes with basal CSF Alzheimer's Disease biomarkers in elderly cognitive healthy subjects

Carles Falcon^1,2, Alan Tucholka¹, Juan Domingo Gispert^1,2, Gemma Cristina Monte-Rubio³, Lorena Rami^3,4, and Jose Luis Molinuevo^3,4

¹BarcelonaBeta Brain Research Center. Pasqual Maragall Foundation, Barcelona, Spain, ²CIBER-BBN, Barcelona, Spain, ³Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ⁴Neurology, Hospital Clinic of Barcelona, Barcelona, Spain

We report the correlation of two-year gray matter (GM) changes with basal levels of Aβ42, p-tau and p-tau/Aβ42 in CSF on a sample of 62 cognitively normal subjects (18 Aβ42 positive and 26 p-tau positive), aged 60-80. GM volume decrease was correlated with Aβ42 in medial and orbital frontal, precuneus, cingulate, medial temporal regions and cerebellum. Correlations with p-tau were located in left hippocampus, parahippocampus and striatal nuclei and with p-tau/Aβ42 in ventral and medial temporal areas. We conclude that diverse pathological mechanisms in the preclinical stage could underpin atrophy rates in different regions known to be altered in AD

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