Meeting Banner
Abstract #1268

The joint effects of APOE genotype and age on functional network in non-demented old adults

Liang Gong1, Hao Su1, Cancan He1, Qing Ye1, Feng Bai1, Chunming Xie1, and Zhijun Zhang1

1Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China, People's Republic of

A cross-sectional resting-state functional magnetic resonance imaging study was conducted with 84 aMCI subjects (including 9 APOE ε2, 45 ε3, 28 ε4 carriers) and well-matched 124 cognitively normal (CN) healthy elders (including 35 APOE ε2, 43 ε3, 46 ε4 carriers). The finding revealed that the ε2 carriers and ε4 carriers showed convergent effects on right AFC but divergent effects on left AFC network when CN compared to aMCI patients. Interactive effects of APOE genotypes and age on AFC network further revealed neural basis of ten years earlier on the age of onset in aMCI patients. Further, mediation analysis suggested that connectivity strength mediated the effects of APOE genotypes and age on the cognitive function in aMCI patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here