Mark J Lowe1, Wanyong Shin1, Balu Krishnan2, Lael Stone2, and Andreas Alexopoulos2
1Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 2Neurlogic Institute, Cleveland Clinic, Cleveland, OH, United States
Recent
reports indicate that cerebrovascular reactivity (CR) may be impaired in
multiple sclerosis (MS). Here we report initial studies to use simultaneous
measurements of electroencephalography (EEG), regional cerebral blood flow, and
BOLD during performance of a motor task. We show that it is possible to produce
EEG estimators of a healthy control subject that correlate very highly with
BOLD measurements, while the same measurements in an age and gender matched MS
patient have a much lower correspondence. Although inconclusive due to the
small sample, the methodology shows promise for helping to understand possible
CR issues in MS.
