Abstract #1311

Quantitative T2 and atrophy in multiple sclerosis: A retrospective 7-year study using standard clinical brain images

Md. Nasir Uddin¹, Kelly C. McPhee², Gregg Blevins³, and Alan H. Wilman¹

¹Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, ²Department of Physics, University of Alberta, Edmonton, AB, Canada, ³Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada

Proton density and T₂-weighted images are frequently used in clinical MS exams. These two images can be used to obtain accurate T₂ by fitting them with prior knowledge of RF pulse shapes and refocusing flip angles in order to compensate for indirect and stimulated echo contributions. After demonstrating feasibility in healthy controls, we investigate 7-year changes in T₂ in subcortical grey matter in 14 relapsing remitting MS patients and related these with disease severity and brain atrophy.

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