Quantitative T2 and atrophy in multiple sclerosis: A retrospective 7-year study using standard clinical brain images
Md. Nasir Uddin1, Kelly C. McPhee2, Gregg Blevins3, and Alan H. Wilman1
1Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Department of Physics, University of Alberta, Edmonton, AB, Canada, 3Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada
Proton density and T2-weighted images
are frequently used in clinical MS exams. These two images can be used to obtain accurate
T2 by fitting them with prior knowledge of RF pulse shapes and refocusing
flip angles in order to compensate for indirect and stimulated echo
contributions. After demonstrating
feasibility in healthy controls, we investigate 7-year changes in T2
in subcortical grey matter in 14 relapsing remitting MS patients and related
these with disease severity and brain atrophy.
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