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Abstract #1311

Quantitative T2 and atrophy in multiple sclerosis: A retrospective 7-year study using standard clinical brain images

Md. Nasir Uddin1, Kelly C. McPhee2, Gregg Blevins3, and Alan H. Wilman1

1Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Department of Physics, University of Alberta, Edmonton, AB, Canada, 3Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada

Proton density and T2-weighted images are frequently used in clinical MS exams. These two images can be used to obtain accurate T2 by fitting them with prior knowledge of RF pulse shapes and refocusing flip angles in order to compensate for indirect and stimulated echo contributions. After demonstrating feasibility in healthy controls, we investigate 7-year changes in T2 in subcortical grey matter in 14 relapsing remitting MS patients and related these with disease severity and brain atrophy.

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