Abstract #1324

Non-Gaussian diffusion weighted imaging in the head and neck; how we can improve the clinical diagnostic accuracy beyond ADC

Mami Iima^1,2, Akira Yamamoto¹, Shigeru Hirano³, Ichiro Tateya³, Morimasa Kitamura³, and Kaori Togashi¹

¹Department of Diagnostic Imaging and Nuclear Medicine, Graduate Schoolof Medicine, Kyoto University, Kyoto, Japan, ²The Hakubi Center for Advancer Research, Kyoto University, Kyoto, Japan, ³Department of Otolaryngology, Graduate Schoolof Medicine, Kyoto University, Kyoto, Japan

The usefulness of non-Gaussian diffusion parameters for the clinical diagnostic ability in the head and neck was evaluated. 135 (62 malignant/63 benign/10 inflammation) patients were prospectively recruited, and non-Gaussian DWI and IVIM parameters as well as synthetic ADC, which comprises both Gaussian and non-Gaussian effect, were estimated from the DWI datasets with multiple b values. Significant difference in each parameter was observed between malignant and benign lesions. There was a significant difference between inflammation or lymphatic vascular malformation and tumors in K or fIVIM values, providing the potential to improve the DWI diagnostic accuracy by complementing their diagnostic abilities.

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