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Abstract #1329

Alterations of resting-state fMRI measurements in individuals with cervical dystonia

Zhihao Li1,2, CecĂ­lia N Prudente3,4, Randall Stilla3, Krish Sathian5,6, Hyder A Jinnah7, and Xiaoping Hu2

1Affective and Social Neuroscience, Shenzhen University, Shenzhen, China, People's Republic of, 2Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States, 3Neurology, Emory University, Atlanta, GA, United States, 4Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, MN, United States, 5Neurology, Rehabilitation Medicine, Psychology, Emory University, Atlanta, GA, United States, 6Rehabilitation R&D Center for Visual & Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, GA, United States, 7Neurology, Human Genetics and Pediatrics, Emory University, Atlanta, GA, United States

Cervical dystonia (CD) is a neurological movement disorder where the pathophysiology remains to be characterized. The present rfMRI study explored CD-associated brain alterations of (i) functional connectivity (FC), (ii) fractional amplitude of low frequency fluctuation (fALFF), and (iii) regional homogeneity (ReHo). The results revealed 25 significant regional alterations that confirm and extend existing knowledge. Additionally, using these regional alterations as diagnostic features, a support vector machine classifier identified 8 features that together yielded a maximum classification accuracy of 97%.

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