Abstract #1339

Relationships between intratumoral heterogeneity parameters using diffusion, perfusion MRI, and FDG PET in head and neck cancer

Su Jin Lee¹, Jin Wook Choi², and Miran Han²

¹Nuclear Medicine, Ajou University School of Medicine, Suwon, Korea, Republic of, ²Radiology, Ajou University School of Medicine, Suwon, Korea, Republic of

MRI and PET can provide tumor biology information noninvasively. ADC from DWI can represent cellularity, DCE-MRI can provide microcirculation, and FDG PET can provide tumor metabolism. Intratumoral heterogeneity is often associated with adverse tumor biology and it can be assessed by these imaging parameters. Tumor heterogeneity on DWI can be simply evaluated by the difference between minimum and maximum ADC value. Metabolism to perfusion ratio can be calculated using DCE-MRI and FDG PET. Texture analysis of PET can be used to evaluate tumor heterogeneity. Thus we investigated the relationships between intraheterogeneity parameters derived from multimodality imaging.

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