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Abstract #1341

The value of combining conventional, diffusion-weighted and dynamic contrast-enhanced MR imaging for the diagnosis of parotid gland tumors

Xiaofeng Tao1, gongxin yang1, Yingwei Wu2, huimin shi1, pingzhong wang1, yongming Dai3, wenjing zhu1, Weiqing gao1, and qiang yu1

1Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, shanghai, China, People's Republic of, 2Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, People's Republic of, 3PHLIPS healthcare China, shanghai, China, People's Republic of

The aim of this study was to determine the value of combining conventional MR imaging (MRI), diffusion-weighted (DW-MRI) and dynamic contrast enhanced MRI (DCE-MRI) in diagnosing solid neoplasms in the parotid gland. Materials and Methods:A total of 148 subjects (101 with benign and 47 with malignant tumors) were evaluated with conventional MRI, DW-MRI and DCE-MRI prior to surgery and pathologic verification. The items observed with conventional MRI included the shape, capsule and signal intensity of parotid masses. The apparent diffusion coefficient (ADC) was calculated from DW-MRI that was obtained with a b factor of 0 and 1000 s/mm2. A time-intensity curve (TIC) was obtained from DCE-MRI. Results:There were significant differences (p<0.01) in the shape, capsule, ADC and TIC between benign and malignant parotid tumors. Irregular neoplasms without capsule, ADC < 1.12×10-3mm2/s, and a plateau enhancement pattern were valuable parameters for predicting malignant neoplasms. A combination of all of these parameters yielded sensitivity, specificity, accuracy, and positive and negative predictive values of 85.1%, 94.1%, 91.2%, and 87.0% and 93.1%, respectively. Conclusion:A combined analysis using conventional MRI, DW-MRI and DCE-MRI is helpful to distinguish benign from malignant tumors in the parotid gland.

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