Abstract #1365

Fast Imaging Employing Steady-State Acquisition of Brain Metastasis: from mouse to woman

Donna H Murrell^1,2, Keng Yeow Tay³, Eugene Wong^2,3, Ann F Chambers^2,3, Francisco Perera³, and Paula J Foster^1,2

¹Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada, ²Department of Medical Biophysics, Western University, London, ON, Canada, ³London Health Sciences Centre, London, ON, Canada

Brain metastatic burden may be underestimated in the clinic because some tumors are impermeable to Gadolinium (Gd). Preclinical studies by our group demonstrated that fast imaging employing steady-state acquisition (FIESTA) was advantageous for detecting small Gd-impermeable tumors. Here, we show clinical translation of this imaging strategy. We present FIESTA images of human brain metastasis alongside standard clinical MRI and illustrate potential clinical utility of this sequence. Initial data suggests FIESTA can visualize intra-tumor heterogeneity where standard clinical MRI could not. Additional lesions were observed in FIESTA; we hypothesize some may be arachnoid cysts, though metastasis cannot be ruled out.

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