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Abstract #1365

Fast Imaging Employing Steady-State Acquisition of Brain Metastasis: from mouse to woman

Donna H Murrell1,2, Keng Yeow Tay3, Eugene Wong2,3, Ann F Chambers2,3, Francisco Perera3, and Paula J Foster1,2

1Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada, 2Department of Medical Biophysics, Western University, London, ON, Canada, 3London Health Sciences Centre, London, ON, Canada

Brain metastatic burden may be underestimated in the clinic because some tumors are impermeable to Gadolinium (Gd). Preclinical studies by our group demonstrated that fast imaging employing steady-state acquisition (FIESTA) was advantageous for detecting small Gd-impermeable tumors. Here, we show clinical translation of this imaging strategy. We present FIESTA images of human brain metastasis alongside standard clinical MRI and illustrate potential clinical utility of this sequence. Initial data suggests FIESTA can visualize intra-tumor heterogeneity where standard clinical MRI could not. Additional lesions were observed in FIESTA; we hypothesize some may be arachnoid cysts, though metastasis cannot be ruled out.

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