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Abstract #1377

Withdrawn - Value of Amide Proton Transfer Imaging in Correlation with Histopathological Grades of Adult Diffuse Gliomas : Comparison and Incremental Value with Dynamic Susceptibility Contrast-Enhanced MRI and Diffusion Weighted Imaging

Seung-Koo Lee1, Yoon Seong Choi2, Sung Soo Ahn1, Ho-Joon Lee1, and Jinna Kim1

1Seoul, Korea, Republic of, 2Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of

We investigated the difference in APT values according to histopathological grades, and compared the diagnostic value of APT with relative cerebral blood volume (rCBV) from dynamic susceptibility contrast-enhanced (DSC) MRI and apparent diffusion coefficient (ADC) from diffusion weighted imaging (DWI) for histopathological grades in adult diffuse gliomas. We optimized APT imaging protocol for clinical setting and found that APT values were increased along with glioma grades, and APT values has incremental values over ADC values for glioma grading. We suggest that APT imaging can be a useful noninvasive imaging biomarker for glioma grading, in combination with ADC.

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