Abstract #1417

Physiological Fluctuations in the White Matter of Children with Sickle Cell Disease

Jackie Leung¹, Zahra Shirzadi², Bradley MacIntosh^2,3, and Andrea Kassner^1,4

¹Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴Medical Imaging, University of Toronto, Toronto, ON, Canada

The pulsatility of the brain has been previously shown to be associated with cerebrovascular dysfunction. Recently, the use resting state BOLD imaging has been proposed to non-invasively assess this pulsatility by calculating the temporal variance in the white matter. This measure is known as physiological fluctuation in the white matter (PF_wm). In this study, we compared PF_wmacquired in children with sickle cell disease to healthy controls. The results show increased pulsatility in the disease group, providing evidence that this approach has the potential to be a clinically relevant tool in the assessment of cerebrovascular diseases.

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