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Abstract #1417

Physiological Fluctuations in the White Matter of Children with Sickle Cell Disease

Jackie Leung1, Zahra Shirzadi2, Bradley MacIntosh2,3, and Andrea Kassner1,4

1Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4Medical Imaging, University of Toronto, Toronto, ON, Canada

The pulsatility of the brain has been previously shown to be associated with cerebrovascular dysfunction. Recently, the use resting state BOLD imaging has been proposed to non-invasively assess this pulsatility by calculating the temporal variance in the white matter. This measure is known as physiological fluctuation in the white matter (PFwm). In this study, we compared PFwm acquired in children with sickle cell disease to healthy controls. The results show increased pulsatility in the disease group, providing evidence that this approach has the potential to be a clinically relevant tool in the assessment of cerebrovascular diseases.

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