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Abstract #1422

Blood T1 and CBF Quantification in ASL MRI

Hua-Shan Liu1,2,3,4, Abbas F Jawad5, Nina Laney6, Erum A Hartung7, Allison M Port8, Ruben C Gur9, Stephen Hooper10, Jerilynn Radcliffe11, Susan L Furth6,12, and John A Detre13

1Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 2Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan, 3Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan, 4Translational Imaging Research Center, Taipei Medical University, Taipei, Taiwan, 5Department of Pediatrics, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 6Division of Nephrology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States, 7Division of Nephrology, Department of Pediatrics, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 8Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States, 9Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States, 10Department of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, NC, United States, 11Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 12Division of Nephrology, Departments of Pediatrics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 13Departments of Neurology and Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States

We evaluated three different approaches to blood T1 used to model ASL CBF measurements in a cohort of children with chronic kidney disease and controls. We observed significant changes in blood T1 depending on the approach used, leading to different results for both sex and group differences in CBF. Our results highlight the importance of blood T1 in ASL CBF quantification and suggest that hematocrit-based T1 may be the optimal approach if hematocrit can be measured at the time of the scan, especially for studies in patients with anemia.

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