Abstract #1459

Comparative Analysis by Magnetic Resonance Imaging of Extracellular Space Diffusion in the Young and Adult Rats

Shuangfeng Yang¹, Hongbin Han^2,3, Yan Wang¹, and Yun Peng¹

¹Imaging Center, Beijing Children's Hospital, Beijing, China, People's Republic of, ²Department of Radiology, Peking University Third Hospital, Beijing, China, People's Republic of, ³Beijing Key Lab of Magnetic Resonance Imaging Device and Technique, Beijing, China, People's Republic of

The brain extracellular space is an irregular and tortuous space among neural cells and capillaries. Its normal development is important to maintain electrical signal conduction between cells, material transport and so on, especially in the early stage after birth, during which angiogenesis is not yet complete. ECS may provide the main pathway for metabolites. In the present study, gadolinium-diethylenetriaminepentaacetic acid tracer-based magnetic resonance imaging was employed to realize dynamic imaging and quantitative analysis of the diffusion and clearance of substances in the rat brain in vivo. With this method the differences of diffusion parameters in the young and adult rats can be detected.

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