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Abstract #1462

Neuroanatomical abnormalities in a PAX6 deficient mouse model studied by Voxel Based Morphometry

Khan Hekmatyar1, Anastasia M Bobilev2, Kenji K Johnson2, and James D Lauderdale2

1BioImaging Research Center, University of Georgia, Athens, GA, United States, 2Department of Genetics, University of Georgia, Athens, GA, United States

Heterozygous PAX6 mutations confines not only defects in eye, but also in the brain. Our MRI study reveals the structural abnormalities in the brain of mouse model of Small EyeNeu (PAX6 Sey Neu/+) and compare with clinical form of this disease using voxel based morphometry using magnetic resonance imaging.

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