Abstract #1464

Effects of High-Fat Diet on White Matter Integrity: A Diffusion Tensor Imaging Study in Wistar Rats.

Andrzej R. Gaździński¹, Yu Zhang², Jarosław Orzeł^3,4, Bartosz Kossowski⁵, Piotr Bogorodzki⁵, Zuzanna Setkowicz⁶, and Stefan P. Gazdzinski⁷

¹Military Institute for Aviation Medicine, Warsaw, Poland, ²University of California San Francisco, San Francisco, CA, United States, ³Faculty of Electronics and Information Technology, Warsaw University of Technology, Warsaw, Poland, ⁴Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland, ⁵Warsaw University of Technology, Warsaw, Poland, ⁶Neuroanatomy, Jagiellonian University, Krakow, Poland, ⁷CNS Lab, Military Institute for Aviation Medicine, Warsaw, Poland

Human DTI studies have demonstrated lower fractional anisotropy and higher mean diffusivity in obese humans. In animal models, high-fat diet is commonly used to induce obesity. However, we observed increase in hippocampal volumes and hippocampal metabolite concentrations in our study of long term effects of high fat diet on brain morphology, function, and behavior in Wistar rats. The rusults of this DTI study are partially consistent with our previous results. Unchanged or increasing mean diffusivity in certain brain regions likely reflects increased concentration of water. It would lead to lower concentration of metabolites, which is contradictory to our earlier findings.

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