Meeting Banner
Abstract #1466

Longitudinal MRI characterizes the impact of prenatal irradiation on ageing

Tine Verreet1,2, Janaki Raman Rangarajan3,4,5, Kristof Govaerts5,6, Frederik Maes3,4, Sarah Baatout1, Lieve Moons2, Mohammed A Benotmane1, and Uwe Himmelreich5,6

1Radiobiology Unit, Molecular and Cellular Biology, Belgian Nuclear Research Centre, SCKā€¢CEN, Mol, Belgium, 2Laboratory of Neural Circuit Development and Regeneration, University of Leuven (KU Leuven), Leuven, Belgium, 3Electrical Engineering (ESAT-PSI), University of Leuven (KU Leuven), Leuven, Belgium, 4Medical IT, iMinds, Leuven, Belgium, 5Molecular Small Animal Imaging Center (MoSAIC), Faculty of Medicine, University of Leuven (KU Leuven), Leuven, Belgium, 6Biomedical MRI Unit, Department of Imaging and Pathology, Faculty of Medicine, University of Leuven (KU Leuven), Leuven, Belgium

Prenatal exposure to ionising radiation can severely compromise brain development, leading to functional impairment of the brain. Behavioral deficits and/or morphological alterations have been reported, but the consequences of prenatal irradiation at older age remains unexplored. We irradiated pregnant mice with different doses (0.05 to 1.0Gy) at embryonic day 11 and investigated structural sequelae at an old age using in vivo longitudinal MRI. Apart from small brain size, we noticed predominant regional changes and increase in brain volume as the mice aged (unlike humans). Hippocampus seems to be affected by exposure to even low-doses and relates to impaired spatio-cognitive performance.

This abstract and the presentation materials are available to members only; a login is required.

Join Here