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Abstract #1488

Improved Pseudo Continuous Arterial Spin Labeling Efficiency Robustness to Off Resonance and High Velocity

Li Zhao1 and David C Alsop1

1Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States

Pseudo continuous arterial spin labeling (pCASL) studies can be degraded by magnetic field variations at the labeling plane. We demonstrate through simulations that high velocity efficiency is particularly vulnerable to field offsets. By changing labeling parameters from published recommendations and/or introducing a new RF pulse, the off-resonance sensitivity and peak systolic velocity sensitivity of pCASL can be reduced. Preliminary experimental comparisons of parameters are reported.

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