Measurement of the Resonance Frequency of Macromolecular Protons in Brain
Xu Jiang1,2, Peter van Gelderen1, and Jeff H. Duyn1
1AMRI, LFMI, NINDS, NIH, Bethesda, MD, United States, 2Physics, University of Maryland, College Park, MD, United States
Studying the spectral asymmetry in Magnetization
Transfer (MT) is essential for precise estimation of MT-related parameters from
off-resonance MT experiments. Measurement of the delay-dependent water proton
saturation following composite MT pulses was used to determine parameters for a
2-pool exchange model. These parameters were further used to calculate
saturation levels of macromolecular protons (MPs) following off-resonance MT
pulses. The off-resonance frequency for MPs is found to be -2.7ppm from water for fixed marmoset brain, and -2.56ppm for human brain. This is consistent with previous studies.
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