Abstract #1502

Measurement of the Resonance Frequency of Macromolecular Protons in Brain

Xu Jiang^1,2, Peter van Gelderen¹, and Jeff H. Duyn¹

¹AMRI, LFMI, NINDS, NIH, Bethesda, MD, United States, ²Physics, University of Maryland, College Park, MD, United States

Studying the spectral asymmetry in Magnetization Transfer (MT) is essential for precise estimation of MT-related parameters from off-resonance MT experiments. Measurement of the delay-dependent water proton saturation following composite MT pulses was used to determine parameters for a 2-pool exchange model. These parameters were further used to calculate saturation levels of macromolecular protons (MPs) following off-resonance MT pulses. The off-resonance frequency for MPs is found to be -2.7ppm from water for fixed marmoset brain, and -2.56ppm for human brain. This is consistent with previous studies.

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