Abstract #1519

Insight into the Quantitative Metrics of Chemical Exchange Saturation Transfer (CEST) Imaging

Hye-Young Heo^1,2, Dong-Hoon Lee¹, Yi Zhang¹, Xuna Zhao¹, Shanshan Jiang¹, and Jinyuan Zhou^1,2

¹The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Amide proton transfer (APT) imaging is a novel chemical exchange saturation transfer (CEST)-based MRI modality that can detect various endogenous mobile proteins and peptides in tissue, such as those in the cytoplasm. The APT quantification results depend on the CEST metrics, which is undesirable. In this study, four CEST metrics: (i) CEST ratio (CESTR), (ii) CESTR normalized with the reference value (CESTR^nr), (iii) inverse Z-spectrum-based (MTR_Rex), and (iv) apparent exchange-related relaxation (AREX), were compared using five-pool Bloch equation-based simulations with varied RF saturation powers and magnetic field strength, and in an in vivo rat tumor study at 4.7 T.

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