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Abstract #1533

3T longitudinal relaxation of human blood with hemoglobin S

Meher Juttukonda1, Manus Donahue1, Melissa Gindville2, and Lori Jordan2

1Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2Pediatrics, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, United States

Quantitative CBF maps derived from pseudo-continuous ASL (pCASL) may be useful in assessing stroke risk in sickle cell anemia (SCA) patients, but T1 relaxation of SCA blood must first be characterized. Venous blood samples were collected from SCA patients as well as normal subjects, and an inversion recovery approach was used to quantify the T1 relaxation times ex vivo. For similar hematocrit, oxygenation, and temperature, T1 relaxation times of SCA blood appear similar to those of normal blood. Therefore, computation of CBF in SCA patients may not be affected by the assumption of normal blood T1 relaxation.

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