Abstract #1533

3T longitudinal relaxation of human blood with hemoglobin S

Meher Juttukonda¹, Manus Donahue¹, Melissa Gindville², and Lori Jordan²

¹Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ²Pediatrics, Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, United States

Quantitative CBF maps derived from pseudo-continuous ASL (pCASL) may be useful in assessing stroke risk in sickle cell anemia (SCA) patients, but T₁ relaxation of SCA blood must first be characterized. Venous blood samples were collected from SCA patients as well as normal subjects, and an inversion recovery approach was used to quantify the T₁ relaxation times ex vivo. For similar hematocrit, oxygenation, and temperature, T₁ relaxation times of SCA blood appear similar to those of normal blood. Therefore, computation of CBF in SCA patients may not be affected by the assumption of normal blood T₁ relaxation.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.