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Abstract #1538

Repeatability and sample size estimations for myelin water imaging

Thibo Billiet1, Stefan Sunaert1, Bea Van den Bergh1, Ronald Peeters1, Mathieu Vandenbulcke1, and Louise Emsell1

1KU Leuven, Leuven, Belgium

Currently, only single slice repeatability results for myelin water imaging (MWI) metrics are available. We assessed the within- and between-subject variation of the myelin water fraction (MWF); intra- and extracellular water fraction (IEWF), and intra- and extracellular water geometric mean T2 time (IEW-gmT2) in a whole cerebrum MWI sequence1 We demonstrated good within- and between subject variability, comparable to previous single-slice results. Future studies may benefit from sample size estimations documented in this work.

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